Between 2004 and 2007, the National Institutes of Health conducted a STEP study.
The STEP Study is the name of a clinical trial to test an experimental human immunodeficiency virus (HIV) vaccine that aimed to stimulate production of immune system T cells that can kill HIV-infected cells. The study enrolled 3,000 participants at sites in Australia, Brazil, Canada, the Dominican Republic, Haiti, Jamaica, Peru, Puerto Rico, and the United States.
On the basis of its first evaluation of vaccine efficacy, the findings were as follows:
The investigators of the vaccine trials have decided to cease immunizations and are contacting study volunteers to inform them of the developments.
Prior to beginning this study, how would you have described the risks and benefits of the study to participants?
Share your thoughts and discuss the ethical issues surrounding this study at the beginning and at the time the decision was made to terminate the study.
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